人員職掌

陳慧玲 Huey-Ling Chen

教授

醫學教育, 兒科學, 肝炎防治

期刊論文

2016  Wen WH, Huang CW, Chie WC, Yeung CY, Zhao LL, Lin WT, Wu JF, Ni YH, Hsu HY, Chang MH, Lin LH, Chen HL*. Quantitative maternal hepatitis B surface antigen predicts maternally transmitted hepatitis B virus infection. Hepatology 2016; 64(5): 1451-1461. [PubMed Abstract]

2016  Ni YH*, Chang MH, Jan CF, Hsu HY, Chen HL, Wu JF, Chen DS. Continuing Decrease in Hepatitis B Virus Infection 30 Years After Initiation of Infant Vaccination Program in Taiwan. Clin Gastroenterol Hepatol 2016; 14(9): 1324-1330. [PubMed Abstract]

2016  Shen WC, Liang PC, Wu JF, Hsu CT, Chen HS, Chen HL*. Combined transarterial embolization and propranolol as effective treatment for hepatic hemangioma with Kasabach-Merritt Syndrome and heart failure in a neonate. Pediatr Neonatol 2016; S1875-9572. [PubMed Abstract]

2016  Wu FY, Liao YW, Wu JF, Chen HL, Hsu HY, Chang MH, Ni YH*. A Simple and Rapid Test-card Method to Detect Hepatitis B Surface Antigen and Antibody: Potential Application in Young Children and Infants. Pediatr Neonatol 2016; 57(3): 219-24. [PubMed Abstract]

2016  Liu YW, Wu JF, Chen HL, Hsu HY, Chang MH, Hsu WC, Tseng PH, Wang HP, Ni YH*. The correlation between endoscopic reflux esophagitis and combined multichannel intraluminal impedance-pH monitoring in children. Pediatr Neonatol 2016; 57(5): 385-389. [PubMed Abstract]

2016  Chang KC, Wu JF, Hsu HY, Chen HL, Ni YH, Chang MH*. Entecavir treatment in children and adolescents with chronic Hepatitis B Virus infection. Pediatr Neonatol 2015; 57(5): 390-395. [PubMed Abstract]

2016  Wu JF, Chiu YC, Chang KC, Chen HL, Ni YH, Hsu HY, Chang MH*. Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood. Hepatology. 2016; 63(1): 74-82. [PubMed Abstract]

2015  Chen HL, Lee CN, Chang CH, Ni YH, Shyu MK, Chen SM, Hu JJ, Lin HH, Zhao LL, Mu SC, Lai MW, Lee CL, Lin HM, Tsai MS, Hsu JJ, Chen DS, Chang KA, Chang MH*. Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus. Hepatology 2015; 62(2): 375-86. [PubMed Abstract]

2014  Chen CY, Chen HL, Chou HC, Tsao PN, Hsieh WS, Chang MH*. Weight-based policy of hepatitis B vaccination in very low birth weight infants in taiwan: a retrospective cross-sectional study. PLoS One 2014; 9:e92271. [PubMed Abstract]

2014  Wu JF, Ni YH, Chen HL, Hsu HY, Chang MH*.The impact of hepatitis B virus precore/core gene carboxyl terminal mutations on viral biosynthesis and the host immune response. J Infect Dis 2014; 209:1374-81. [PubMed Abstract]

2014  Peng SS, Hsu WM, Chen HL, Mo YH*. Using volume index and lateral hepatic angle to differentiate biliary atresia from TPN-associated cholestasis. J Pediatr Gastroenterol Nutr 2014; 59:403-8. [PubMed Abstract]

2014  Wu JF, Tsai WY, Tung YC, Chen HL, Ni YH, Hsu HY, Chang MH*. Effect of menarche onset on the clinical course in females with chronic hepatitis B virus infection. J Pediatr 2014; 165:534-8. [PubMed Abstract]

2014  Chiu YC, Liao SF, Wu JF, Lin CY, Lee WC, Chen HL, Ni YH, Hsu HY, Chang MH*. Factors affecting the natural decay of hepatitis B surface antigen in children with chronic hepatitis B Virus infection during long-term follow-up. J Pediatr 2014 [PubMed Abstract]

2014  Lu FT, Wu JF, Hsu HY, Ni YH, Chang MH, Chao CI, Chen HL*. Gamma-glutamyl transpeptidase level as a screening marker among diverse etiologies of infantile intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 2014. [PubMed Abstract]

2014  Wu JF, Tsai WY, Tung YC, Chen HL, Ni YH, Hsu HY, Chang MH*. Role of serum dehydroepiandrosterone sulfate level on the clearance of chronic hepatitis B virus infection. J Gastroenterol 2014; 49:900-906. [PubMed Abstract]

2013  Hsu HY, Chang MH, Ni YH, Jeng YM, Chiang CL, Chen HL, Wu JF, Chen PJ*. Long-term follow-up of children with postnatal immunoprophylaxis failure who were infected with hepatitis B virus surface antigen gene mutant. J Infect Dis 2013; 207:1047-1057. [PubMed Abstract]

2013  Su WJ, Chen HL, Chang MH*. Breakthrough hepatitis B Virus (HBV) infection from mother-to-infant transmission is the key problem hindering HBV eradication. J Infect Dis 2013; 208:1036-1037. [PubMed Abstract]

2013  Chen CY, Ho MC, Wu JF, Jeng YM, Chen HL, Chang MH, Lee PH, Hu RH, Ni YH*. Development of autoantibodies after pediatric liver transplantation. Pediatr Transplant 2013; 17:144-148. [PubMed Abstract]

2013  Chen HL*. Mining the idiopathic genetic cholestasis syndrome. J Gastroenterol Hepatol 2013; 28:389-391. [PubMed Abstract]

2013  Wen WH, Chang MW, Zhao LL, Ni YH, Hsu HY, Wu JF, Chen PJ, Chen DS, Chen HL*. Mother-to-infant transmission of hepatitis B virus infection: Significance of maternal viral load and strategies for intervention. J Hepatol 2013; 59:24-30. [PubMed Abstract]

2012  Chen ST, Su YN, Ni YH, Hwu WL, Lee NC, Chien YH, Chang CC, Chen HL, Chang MH*. Diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency using high-resolution melting analysis and a clinical scoring system. J Pediatr 2012; 161:626-631. [PubMed Abstract]

2012  Chen HL, Chen HL, Yuan RH, Wu SH, Chen YH, Chien CS, Chou SP, Wang R, Ling V, Chang MH*. Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile acid stress. J Cell Mol Med 2012; 16):2679-2689. [PubMed Abstract]

2012  Mo YH, Chen HL, Hsu WM, Peng SS*. Less-invasive MR indices of clinically evident esophageal variceal bleeding in biliary atresia patients. J Formos Med Assoc 2012; 111:482-488. [PubMed Abstract]

2012  Wu JF, Kao PC, Chen HL, Lai HS, Hsu HY, Chang MH, Ni YH*. A high serum interleukin-12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia. Liver Int 2012; 32:1557-1563. [PubMed Abstract]

2012  Wu JF, Chen CH, Ni YH, Lin YT, Chen HL, Hsu HY, Chang MH*. Toll-like receptor and hepatitis B virus clearance in chronic infected patients: a long-term prospective cohort study in Taiwan. J Infect Dis 2012; 206:662-628. [PubMed Abstract]

2012  Ni YH, Chang MH, Wu JF, Hsu HY, Chen HL, Chen DS*. Minimization of hepatitis B infection by a 25-year universal vaccination program. J Hepatol 2012; 57:730-735. [PubMed Abstract]

2012  Wu JF, Hsu HY, Ni YH, Chen HL, Wu TC, Chang MH*. Suppression of furin by interferon-r and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes. Am J Pathol 2012; 181:19-25. [PubMed Abstract]

2012  Shen YM, Wu JF, Hsu HY, Ni YH, Chang MH, Liu YW, Lai HS, Hsu WM, Weng HL, Chen HL*. Oral absorbable fat-soluble vitamin formulation in pediatric with cholestasis. J Pediatr Gastroenterol Nutr 2012; 55:587-591. [PubMed Abstract]

2012  Wu JF, Su YR, Chen CH, Chen HL, Ni YH, Hsu HY, Wang JL, Chang MH*. Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotypes B and C HBV infected children. J Pediatr Gastroenterol Nutr 2012; 54:97-100. [PubMed Abstract]

2012  Chen HL, Lin LH, Hu FC, Lee JT, Lin WT, Yang YJ, Huang FC, Wu SF, Chen SCC, Wen WH, Chu CH, Ni YH, Hsu HY, Tsai PL, Chiang CL, Shyu MK, Lee PI, Chang FY, Chang MH*. Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV. Gastroenterology 2012; 142:773-781. [PubMed Abstract]

2012  Huang HP, Chang MH, Chen YT, Hsu HY, Chiang CL, Cheng TS, Wu YM, Wu MZ, Hsu YC, Shen CC, Lee CN, Chuang YH, Hong CL, Jeng YM, Chen PH, Chen HL, Lee MS*. Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation. Hepatology 2012; 55:161-172. [PubMed Abstract]

2011  Shen YM, Wu JF, Chen HL, Hsu HY, Chang MW, Hsieh TK, Ni YH*. Characteristics and incidences of pediatric Crohn’s disease in the decades before and after 2000. Pediatr Neonatol 2011; 52:317-320. [PubMed Abstract]

2011  Wen WH, Chen HL, Ni YH, Hsu HY, Kao JH, Hu FC, Chang MH*. Secular trend of viral genotype distribution in children with chronic hepatitis B virus infection after universal infant immunization. Hepatology 2011; 53:429-436. [PubMed Abstract]

2011  Lien TH, Chang MH, Wu JF, Chen HL, Lee HC, Chen AC, Tiao MM, Wu TC, Yang YJ, Lin CC, Lai MW, Hsu HY, Ni YH*. Effect of the infant stool color card screening program on five-year outcome of biliary atresia in Taiwan. Hepatology 2011; 53:202-208. [PubMed Abstract]

2011  Chang KW, Chen HL, Chien YH, Chen TC, Yeh CT*. SLC25A13 gene mutations in Taiwanese patients with non-viral hepatocellular carcinoma. Mol Genet Metab 2011; 103:293-296. [PubMed Abstract]

2011  Tien FM, Wu JF, Jeng YM, Hsu HY, Ni YH, Chang MH, Lin DT, Chen HL*. Clinical features and treatment responses of children with eosinophilic gastroenteritis. Pediatr Neonatol 2011; 52:272-278. [PubMed Abstract]

2011  Lin YC, Chang MH, Liao SF, Wu JF, Ni YH, Tiao MM, Lai MW, Lee HC, Lin CC, Wu TC, Lau BH, Tsai TC, Yang YJ, Chen AC, Shih HH, Lee IH, Lee WC, Chen HL, Hsu HY, Chiou ST*, and the Taiwan Infant Stool Color Card Study Group. Decreasing rate of biliary atresia in Taiwan: a survey, 2004-2009. Pediatrics 2011; 128:e530-536. [PubMed Abstract]

2011  Tseng YR, Wu JF, Ni YH, Chen HL, Chen CC, Wen WH, Hsu HY, Chang MH*. Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection. Liver Int 2011; 31:1373-1380. [PubMed Abstract]

2011  Yang CT, Chen HL, Ho MC, Peng SS*. Computed tomography indices and criteria for prediction of esophageal variceal bleeding in survivors of biliary atresia awaiting liver transplantation. Asian J Surg 2011; 34:168-174. [PubMed Abstract]

2011  Chou HC, Chen MH, Yang HI, Su YN, Hsieh WS, Chen CY, Chen HL, Chang MH, Tsao PN*. 211 G to A variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice. Pediatr Res 2011; 69:170-174. [PubMed Abstract]

2010  Wu JF, Wu TC, Chen CH, Ni YH, Chen HL, Hsu HY, Chang MH*. Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion. Gastroenterology 2010; 138:165-172. [PubMed Abstract]

2010  Hsu HY, Chang MH, Ni YH, Chiang CL, Chen HL, Wu JF, Chen PJ*. No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization. J Infect Dis 2010; 201:1192-1200. [PubMed Abstract]

2010  Su WJ, Ho MC, Ni YH, Wu JF, Jeng YM, Chen HL, Wu YM, Hu RH, Chang MH, Lee PH*. Clinical course of de novo hepatitis B infection after pediatric liver transplantation. Liver Transpl 2010; 16:215-221. [PubMed Abstract]

2010  Yang MC, Chang MH, Chiu SN, Peng SF, Wu JF, Ni YH, Chen HL*. Implication of early-onset biliary atresia and extrahepatic congenital anomalies. Pediatr Int 2010; 52:569-572. [PubMed Abstract]

2010  Wu JF, Tsai WY, Hsu HY, Ni YH, Chen HL, Tsuei DJ, Chang MH*. Effect of puberty onset on spontaneous hepatitis B virus e antigen seroconversion in men. Gastroenterology 2010; 138:942-948.e1. [PubMed Abstract]

2010  Chen CY, Ni YH, Chen HL, Lu FL, Chang MH*. Lamivudine treatment in infantile fulminant hepatitis B. Pediatr Int 2010; 52:672-674. [PubMed Abstract]

2010  Kao PC, Wu JF, Ni YH, Lin YT, Chen HL, Hsu HJ, Hsu HY, Chang MH*. Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance. Liver Int 2010 ;30:1448-1453. [PubMed Abstract]

2009  Wang R, Chen HL, Liu L, Sheps JA, Phillips MJ, Ling V*. Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump. Hepatology 2009; 50:948-956. [PubMed Abstract]

2009  Su WJ, Ho MC, Ni YH, Chen HL, Hu RH, Wu YM, Chang MH, Lee PH*. High-titer antibody to hepatitis B surface antigen before liver transplantation can prevent de novo hepatitis B infection. J Pediatr Gastroenterol Nutr 2009; 48:203-208. [PubMed Abstract]

2009  Hsu YC, Chen HL, Wu MZ, Liu YJ, Lee PH, Sheu JC, Chen CH*. Adult progressive intrahepatic cholestasis associated with genetic variations in ATP8B1 and ABCB11. Hepatol Res 2009; 39:625-631. [PubMed Abstract]

2009  Wu JF, Ho MC, Ni YH, Chen HL, Lu CY, Hsu HY, Lee PH, Chang MH*. Timing of Epstein-Barr virus acquisition and the course of posttransplantation lymphoproliferative disorder in children. Transplantation 2009; 87:758-762. [PubMed Abstract]

2009  Wu JF, Ni YH, Chen HL, Hsu HY, Lai HS, Chang MH*. Humoral immunogenicity to measles, rubella, and varicella-zoster vaccines in biliary atresia children. Vaccine. 2009; 27:2812-2815. [PubMed Abstract]

2009  Yeh SH, Ni YH, Jeng YM, Chen HL, Wu JF, Chang MH*. Emerging importance of autoimmune hepatitis in children in Taiwan, an endemic area for viral hepatitis. Pediatr Neonatol 2009; 50:65-69. [PubMed Abstract]

2009  Chen CY, Chen HL*. The risk factors of parenteral nutrition-associated cholestasis in preterm infants. (editorial) Pediatr Neonatol 2009; 50:181-183. [PubMed Abstract]

2009  Chen ST, Chen HL, Ni YH, Chien YH, Jeng YM, Chang MH, Hwu WL*. X-linked liver glycogenosis in a Taiwanese family: transmission from undiagnosed males. Pediatr Neonatol 2009; 50:230-233. [PubMed Abstract]

2009  Ueki I, Kimura A, Chen HL, Yorifuji T, Mori J, Itoh S, Maruyama K, Ishige T, Takei H, Nittono H, Kurosawa T, Kage M, Matsuishi T*. SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency. J Gastroenterol Hepatol. 2009; 24:776-785. [PubMed Abstract]

2008  Ueki I, Kimura A, Nishiyori A, Chen HL, Takei H, Nittono H, Kurosawa T*. Neonatal cholestatic liver disease in an Asian patient with a homozygous mutation in the oxysterol 7alpha-hydroxylase gene. J Pediatr Gastroenterol Nutr 2008; 46:465-469. [PubMed Abstract]

2008  Wu JF, Ni YH, Chen HL, Hsu HY, Lai HS, Chang MH*. Inadequate humoral immunogenicity to recombinant hepatitis B virus vaccine in biliary atresia children. Pediatr Res 2008; 64:100-104. [PubMed Abstract]

2008  Hsiao CH, Chang MH, Chen HL, Lee HC, Wu TC, Lin CC, Yang YJ, Chen AC, Tiao MM, Lau BH, Chu CH, Lai MW*. Taiwan Infant Stool Color Card Study Group. Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology 2008; 47:1233-1240. [PubMed Abstract]

2008  Ni YH, Chang MH, Hsu HY, Tung YC, Chen HL, Wang KJ, Tsuei DJ, Young NC*. Mutations of T-cell epitopes in the hepatitis B virus surface gene in children with chronic infection and hepatocellular carcinoma. Am J Gastroenterol 2008; 103:1004-1009. [PubMed Abstract]

2008  Lin YC, Lai HS, Hsu WM, Lee PI, Chen HL, Chang MH*. Mutation analysis of endothelin-B receptor gene in patients with hirschsprung disease in Taiwan. J Pediatr Gastroenterol Nutr 2008; 46:36-40. [PubMed Abstract]

2008  Chen HL, Liu YJ, Chen HL, Wu SH, Ni YH, Ho MC, Lai HS, Hsu WM, Hsu HY, Tseng HC, Jeng YM, Chang MH*. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr Res 2008; 63:667-673. [PubMed Abstract]

2008  Chen HL, Liu YJ, Su YN, Wang NY, Wu SH, Ni YH, Hsu HY, Wu TC, Chang MH*. Diagnosis of BSEP/ABCB11 mutations in asian patients with cholestasis using denaturing high performance liquid chromatography. J Pediatr 2008; 153:825-832. [PubMed Abstract]

2008  Chen HW, Chen HL, Ni YH, Lee NC, Chien YH, Hwu WL, Huang YT, Chiu PC, Chang MH*. Chubby face and the biochemical parameters for the early diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency. J Pediatr Gastroenterol Nutr 2008; 47:187-192. [PubMed Abstract]

2008  Chen HL, Wang R, Chen HL, Hwu WL, Jeng YM, Chang MH, Ling V*. Bone marrow transplantation results in donor-derived hepatocytes in an animal model of inherited cholestatic liver disease. J Biomed Sci 2008; 15:615-622. [PubMed Abstract]

2008  Chen ST, Chen HL, Su YN, Liu YJ, Ni YH, Hsu HY, Chu CS, Wang NY, Chang MH*. Prenatal diagnosis of progressive familial intrahepatic cholestasis type 2. J Gastroenterol Hepatol 2008; 23:1390-1393. [PubMed Abstract]

2008  Ni YH, Ho MC, Wu JF, Chen HL, Wu YM, Hu RH, Lee PH, Chang MH*. Response to booster hepatitis B vaccines in liver-transplanted children primarily vaccinated in infancy. Transplantation 2008; 86:1531-1535. [PubMed Abstract]

2007  Ni YH, Huang LM, Chang MH, Yen CJ, Lu CY, You SL, Kao JH, Lin YC, Chen HL, Hsu HY, Chen DS*. Two decades of universal hepatitis B vaccination in Taiwan: impact and implication for future strategies. Gastroenterology 2007; 132:1287-1293. [PubMed Abstract]

2007  Bu LN, Chang MH, Ni YH, Chen HL, Cheng CC*. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatr Int 2007; 49:485-490. [PubMed Abstract]

2007  Ni YH, Chang MH, Chen PJ, Tsai KS, Hsu HY, Chen HL, Tsuei DJ, Chen DS*. Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. Gastroenterology 2007; 132:2340-2345. [PubMed Abstract]

2007  Yuan RH, Chen HL, Chen HL, Hsu MK, Lee PH, Chang MH*. Attenuation of  kupffer cell function in acute on chronic liver injury enhanced engraftment of transplanted hepatocytes. World J Surg 2007; 31:1270-1277. [PubMed Abstract]

2007  Su WJ, Chen HL, Lai HS, Ni YH, Chang MH*. Pancreaticobiliary anomalies is the leading cause of childhood recurrent pancreatitis. J Formos Med Assoc 2007; 106:119-125. [PubMed Abstract]

2006  Hung PY, Chen CC, Chen WJ, Lai HS, Hsu WM, Lee PH, Ho MC, Chen TH, Ni YH, Chen HL, Hsu HY, Chang MH*. Long-term prognosis of patients with biliary atresia: a 25 year summary. J Pediatr Gastroenterol Nutr 2006; 42:190-195. [PubMed Abstract]

2006  Lee JH, Chen HL, Chen HL, Ni YH, Hsu HY, Chang MH*. Neonatal  Dubin-Johnson syndrome: long-term follow-up and MRP2 mutations study. Pediatr Res 2006; 59:584-589. [PubMed Abstract]

2006  Lai YC, Ni YH, Jou ST, Ho MC, Wu JF, Chen HL, Hu RH, Jeng YM, Chang MH, Lee PH*. Post-transplantation lymphoproliferative disorders localizing to the gastrointestinal tract after liver transplantation: report of five pediatric cases. Pediatr Transplant 2006; 10:390-394. [PubMed Abstract]

2006  Hsu HY, Ni YH, Chiang CL, Shyu MK, Chen HL, Chang MH*. SEN virus infection in children in Taiwan: transmission route and role in blood transfusion and liver diseases. Pediatr Infect Dis J 2006; 25:390-394. [PubMed Abstract]

2006  Chen SM, Chang MH, Du JC, Lin CC, Chen AC, Lee HC, Lau BH, Yang YJ, Wu TC, Chu CH, Lai MW, Chen HL*. Taiwan Infant Stool Color Card Study Group. Screening for biliary atresia by infant stool color card in Taiwan. Pediatrics 2006; 117:1147-1154. [PubMed Abstract]

2006  Yeh JN, Jen YM, Chen HL, Ni YH, Hwu WL, Hsu HY, Chang MH*. Hepatic steatosis and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in Taiwanese infants. J Pediatr 2006; 148:642-646. [PubMed Abstract]

2006  Wu JF, Chiang BL, Chen HL, Lai HS, Chang MH, Ni YH*. Impaired T-lymphocyte proliferation function in biliary atresia patients with chronic cholestatic jaundice after a Kasai operation. Pediatr Res 2006; 60:602-606. [PubMed Abstract]

2006  Chen SM, Ni YH, Chen HL, Chang MH*. Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan. J Formos Med Assoc 2006; 105:964-970.

2006  Chen HL*. Sonographic diagnosis in infantile cholestasis. Acta Paediatr Taiwan 2006; 47:167-168. [PubMed Abstract]

2006  Tsai CW, Yang CC, Chen HL, Hwu WL, Wu MZ, Liu KL, Wu MS*. Homozygous SLC25A13 mutation in a Taiwanese patient with adult-onset citrullinemia complicated with steatosis and hepatocellular carcinoma. J Formos Med Assoc 2006; 105:852-856. [PubMed Abstract]

2006  Wu JF, Chen CH, Hsieh RP, Shih HH, Chen YH, Li CR, Chiang CY, Shau WY, Ni YH, Chen HL, Hsu HY, Chang MH*. HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: a long-term prospective sibling cohort study in Taiwan. J Pediatr 2006; 148:647-651. [PubMed Abstract]

2006  Lee NC, Chien YH, Kobayashi K, Saheki T, Chen HL, Chiu PC, Ni YH, Chang MH, Hwu WL*. Time course of acylcarnitine elevation in neonatal intrahepatic cholestasis caused by citrin deficiency. J Inherit Metab Dis 2006; 29:551-555. [PubMed Abstract]

2005  Chen HL, Chen HL, Liu YJ, Feng CH, Wu CY, Shyu MK, Yuan RH, Chang MH*. Developmental expression of canalicular transporter genes in human liver. J Hepatol 2005; 43:472-477. [PubMed Abstract]

2005  Wen WH, Chen HL*, Chang MH, Ni YH, Shih HH, Lai HS, Hsu WM*. Fecal elastase 1, serum amylase and lipase levels in children with cholestasis. Pancreatology 2005; 5:432-437. [PubMed Abstract]

2005  Chan PC, Chen HL, Kong MS, Huang FC, Lee HC, Lin CC, Liu CC, Lee IH, Wu TC, Wu SF, Ni YH, Hsu HY, Chang MH*. Factors affecting the mortality of pediatric fulminant hepatic failure in relation to HBV infection. J Gastroenterol Hepatol 2005; 20:1223-1227. [PubMed Abstract]

2005  Wei JM, Chen HL*, Lee PI, Chen CM, Ma CY, Hwu WL*. Reye’s syndrome developing in an infant on treatment of Kawasaki syndrome. J Paediatr Child Health 2005; 41:303-304. [PubMed Abstract]

2005  Wu PS, Chen HL*, Yang YH, Jeng YM, Lee PI, Chang MH*. Intestinal behcet disease presenting as neonatal onset chronic diarrhoea in an 11-month-old male baby. Eur J Pediatr 2005; 164:523-525. [PubMed Abstract]

2005  Shih HH, Lin TM, Chuang JH, Eng HL, Juo SH, Huang FC, Chen CL, Chen HL*. Promoter polymorphism of the CD14 endotoxin receptor gene is associated with biliary atresia and idiopathic neonatal cholestasis. Pediatrics 2005; 116:437-441. [PubMed Abstract]

2005  Ni YH, Huang FC, Wu TC, Kong MS, Jeng YM, Chen PJ, Tsuei DJ, Chen HL, Hsu HY, Chang MH*. Lamivudine treatment in maternally transmitted chronic hepatitis B virus infection patients. Pediatr Int 2005; 47:372-377. [PubMed Abstract]

2005  Huang HP, Tsuei DJ, Wang KJ, Chen YL, Ni YH, Jeng YM, Chen HL, Hsu HY, Chang MH*. Differential integration rates of hepatitis B virus DNA in the liver of children with chronic hepatitis B virus infection and hepatocellular carcinoma. J Gastroenterol Hepatol 2005; 20:1206-1214. [PubMed Abstract]

2005  Wang CW, Wang LC, Chang MH, Ni YH, Chen HL, Hsu HY, Chen DS*. Long-term follow-up of hepatitis B surface antibody levels in subjects receiving universal hepatitis B vaccination in infancy in an area of hyperendemicity: correlation between radioimmunoassay and enzyme immunoassay. Clin Diagn Lab Immunol 2005; 12:1442-1447. [PubMed Abstract]

2004  Chen HL, Chang CJ, Kong MS, Huang FC, Lee HC, Lin CC, Liu CC, Lee IH, Wu TC, Wu SF, Ni YH, Hsu HY, Chen DS*. Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination. Hepatology 2004; 39:58-63. [PubMed Abstract]

2004  Chan PC, Chen HL*, Ni YH, Hsu HY, Chang LY, Lee PI, Chang MH*. Outcome predictors of fulminant hepatic failure in children. J Form Med Asso 2004; 103:432-436. [PubMed Abstract]

2004  Wen WH, Chang MH, Hsu HY, Ni YH, Chen HL*. The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection. J Pediatr 2004; 144:397-399. [PubMed Abstract]

2004  Tsai CH, Chen HL, Ni YH, Hsu HY, Jeng YM, Chang CJ, Chang MH*. Characteristics and trends in incidence of inflammatory bowel disease in Taiwanese children. J Form Med Asso 2004; 103:685-691. [PubMed Abstract]

2004  Chen CY, Tsao PN, Chen HL, Hou HC, Hsieh WS, Chang MH*. Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis. J Pediatr 2004; 145:317-321. [PubMed Abstract]

2004  Hsu HY, Chang MH, Ni YH, Chen HL*. Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan. Gut 2004; 53:1499-1503. [PubMed Abstract]

2004  Ni YH, Chang MH, Wang KJ, Hsu HY, Chen HL, Kao JH, Yeh SH, Jeng YM, Tsai KS, Chen DS*. Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma. Gastroenterology 2004; 127:1733-1738. [PubMed Abstract]

2004  Chen HL, Chang MH*. Growth failure and metabolic bone disease in progressive familial intrahepatic cholestasis (editorial). J Pediatr Gastroenterol Nutr 2004; 39:328-330. [PubMed Abstract]

2004  Chen HL*. Molecular mechanisms of cholestasis. Dec, 2004. PhD Thesis. Graduate Institute of Clinical Medicine, National Taiwan University.

2003  Hsu HY, Ni YH, Chen HL, Kao JH, Chang MH*. TT virus infection in healthy children, children after blood transfusion, and children with non-A to E hepatitis or other liver diseases in Taiwan. J Med Virol 2003; 69:66-71. [PubMed Abstract]

2003  Bu LN, Chen HL, Chang CJ, Ni YH, Hsu HY, Lai HS, Hsu WM, Chang MH*. Prophylactic oral antibiotics in prevention of recurrent cholangitis after the Kasai portoenterostomy. J Pediatr Surg 2003; 38:590-593. [PubMed Abstract]

2003  Hsui JY, Chien YH, Chu SY, Lu FL, Chen HL, Ho MJ, Lee PH, Hwu WL*. Living-related liver transplantation for methylmalonic acidemia: report of one case. Acta Paediatr Taiwan 2003; 44:171-173. [PubMed Abstract]

2003  Wu JF, Chen HL, Peng SS, Yu TW, Lee WT, Chang MH*. Neurofibromatosis type I and intestinal neuronal dysplasia type B in a child: report of one case. Acta Paediatr Taiwan 2003; 44:232-234. [PubMed Abstract]

2002  Chen HL, Chang PS, Hsu HC, Ni YH, Hsu HY, Lee JH, Jeng YM, Shau WY, Chang MH*. FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low-glutamyltranspeptidase levels. J Pediatr 2002; 140:119-124. [PubMed Abstract]

2002  Bu LN, Chen HL, Ni YH, Peng S, Jeng YM, Lai HS, Chang MH*. Multiple intrahepatic biliary cysts in children with biliary atresia. J Pediatr Surg 2002; 37:1183-1187. [PubMed Abstract]

2002  Huang YC, Chen HL, Tsai KS, Tang JR, Ni YH, Chang MH*. Serum gamma-glutamyl transpeptidase activity and bile acids in normal Taiwanese infants. Acta Paediatr Taiwan 2002; 43:245-248. [PubMed Abstract]

2001  Chen HL, Chang PS, Hsu HC, Lee JH, Ni YH, Hsu HY, Jeng YM, Chang MH*.  Progressive familial intrahepatic cholestasis with high gamma-glutamyltranspeptidase levels in Taiwanese infants: role of MDR3 gene defect? Pediatr Res 2001; 50:50-55. [PubMed Abstract]

2001  Wu ET, Chen HL, Ni YH, Lee PI, Hsu HY, Lai HS, Chang MH*. Bacterial cholangitis in patients with biliary atresia: impact on short-term outcome. Pediatr Surg Int 2001; 17:390-395. [PubMed Abstract]

2001  Lee IH, Chen HL, Jeng YM, Cheng MT, Tsao LY, Chang MH*. Congenital generalized lipodystrophy in a 4-month-old infant. J Formos Med Asso 2001; 100:623-627. [PubMed Abstract]

2001  Ni YH, Chang MH, Huang LM, Chen HL, Hsu HY, Hiu TY, Tsai KS, Chen DS*. Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination. Ann Intern Med 2001; 135:796-800. [PubMed Abstract]

2001  Huang YJ, Chen HL, Hsu WM, Chen SJ, Lai MW, Chang MH*. Left paraduodenal hernia presenting as intestinal obstruction: report of one case. Acta Paediatr Taiwan 2001; 42:172-174. [PubMed Abstract]

2000  Yang TY, Chen HL*, Ni YH, Hwu YL, Chang MH*. Hereditary fructose intolerance presenting as Reye's-like syndrome: report of one case. Acta Paediatr Taiwan 2000; 41:218-220. [PubMed Abstract]

2000  Ni YH, Chang MH, Hsu HY, Chen HL*. Long-term follow-up study of core gene deletion mutants in children with chronic hepatitis B virus infection. Hepatology 2000; 32:124-128. [PubMed Abstract]

2000  Chang MH, Shau WY, Chen CJ, Wu TC, Kong MS, Liang DC, Hsu HM, Chen HL, Hsu HY, Chen DS*. Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. JAMA 2000; 284:3040-3042. [PubMed Abstract]

2000  Tsai IJ, Chang MH, Chen HL, Ni YH, Lee PI, Chiu TY*. Immunogenicity and reactogenicity of the combined hepatitis A and B vaccine in young adults. Vaccine 2000; 19:437-441. [PubMed Abstract]

1999  Lin WT, Lin SJ, Ni YH, Chen HL, Wang HP, Chu JS, Chang MH*. Primary sclerosing cholangitis in a child. J Formos Med Assoc 1999; 98:209-213. [PubMed Abstract]

1999  Hsu HY, Chang MH, Liaw SH, Ni YH, Chen HL*. Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in Taiwan. Hepatology 1999; 30:1312-1317. [PubMed Abstract]

1998  Chen HL, Chang MH, Lin HH, Ni YH, Hsu HY, Wang JT, Chen DS*. Antibodies to E2 protein of hepatitis G virus in children: different responses according to age at infection. J Pediatr 1998; 133:382-385. [PubMed Abstract]

1997  Chen HL, Chang MH, Ni YH, Hsu HY, Kao JH, Chen PJ*. Hepatitis G virus infection in normal and prospectively followed posttransfusion children. Pediatr Res 1997; 42:784-787. [PubMed Abstract]

1996  Chen HL, Huang LM, Lee PI, Su IJ, Lin KH, Lee CY*. Late transition from infectious mononucleosis with encephalitis to fatal hemophagocytic syndrome: report of a case. Internat J Pediatr Hematol/Oncol 1996;3:195-200.

1996  Chen HL, Chang MH, Ni YH, Hsu HY, Lee PI, Lee CY, Chen DS*. Seroepidemiology of hepatitis B virus infection in children: ten years of mass vaccination in Taiwan. JAMA 1996; 276:906-908. [PubMed Abstract]

1994  Chen HL, Wang PJ, Young C, Liu HM, Shen YZ*. Tuberous sclerosis associated with hemimegalencephaly. Acta Neurol Sin 1994; 3:139-145.

1994  Chen HL, Wang PJ, Tu YK, Tseng SH, Yao YT, Young C, Shen YZ*. Hemimegalencephaly treated by hemispherectomy: report of two cases. J Formos Med Assoc 1994; 93:961-966. [PubMed Abstract]

財團法人青杏醫學文教基金會  青杏醫學獎,  2009

臺大醫院  優秀年輕同仁傑出研究獎,  2006

兒科醫學會  小兒消化醫學會美強生旅行獎,  2004

財團法人宋瑞樓教授學術基金會  優秀論文獎,  2004

World Congress of Pediatric Gastroenterology, Hepatology and Nutrition  Young Investigator Travel Award,  2000

臺大醫院  主治醫師優秀論文獎,  1999

財團法人肝病防治學術基金會  優秀論文獎,  1998

小兒科學 (醫學系), 小兒科臨床實習乙 (醫學系), 一般醫學保健 (醫衛共同課程), 台灣醫療體驗學習 (醫學系), 家庭社會與醫療 (醫學系), 人與科技體驗學習 (醫學系), 人文與醫學體驗學習 (醫學系), 「PGY課程」倫理教學 (醫學系)